Dominant-Negative Control of Estradiol-Directed Gene Transactivation by an Intracellular Estrogen Binding Protein (Heat shock protein 27; Hsp27) and an Estrogen Response Element Binding Protein (hnRNPC-like Protein)
نویسندگان
چکیده
Coordinate, Dominant-Negative Control of Estradiol-Directed Gene Transactivation by an Intracellular Estrogen Binding Protein (Heat shock protein 27; Hsp27) and an Estrogen Response Element Binding Protein (hnRNPC-like Protein) John S. Adams1, Hong S. Chen2, Martin S. Hewison2 1Orthopaedic Surgery, David Geffen School of Medicine at UCLA, Los Angeles, CA; 2Burns and Allen Research Institute, Cedars-Sinai Medical Center, David Geffen School of Medicine at UCLA, Los Angeles, CA [email protected]
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An Hsp27-related, dominant-negative-acting intracellular estradiol-binding protein.
New World primates (NWPs) exhibit a compensated form of resistance to gonadal steroid hormones. We demonstrated recently that estrogen resistance in NWP cells was associated with the overexpression of two proteins, a nonreceptor-related, dominant-negative-acting estrogen response element (ERE)-binding protein (ERE-BP) and an intracellular estradiol-binding protein (IEBP). Based on the N-termina...
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